Decreasing impact of late relapses on disability worsening in secondary progressive multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Brain atrophy and disability worsening in primary progressive multiple sclerosis: insights from the INFORMS study
Objective To investigate the relationship between brain volume and disability worsening over ≥3 years in the natural history of primary progressive multiple sclerosis using data from the placebo group of the INFORMS trial (n = 487; clinicaltrials.gov NCT00731692). Methods Magnetic resonance imaging scans were collected annually. Brain volume loss was determined using SIENA. Patients were stra...
متن کاملHeart rate variability is differentially altered in multiple sclerosis: implications for acute, worsening and progressive disability
BACKGROUND Sympathovagal imbalance has been associated with poor prognosis in chronic diseases, but there is conflicting evidence in multiple sclerosis. OBJECTIVES The objective of this study was to investigate the autonomic nervous system dysfunction correlation with inflammation and progression in multiple sclerosis. METHODS Heart rate variability was analysed in 120 multiple sclerosis pa...
متن کاملModifiable factors influencing relapses and disability in multiple sclerosis.
A growing body of literature indicates that the natural course of multiple sclerosis can be influenced by a number of factors. Strong evidence suggests that relapses can be triggered by infections, the postpartum period and stressful life events. Vaccinations against influenza, hepatitis B and tetanus appear to be safe. Surgery, general and epidural anaesthesia, and physical trauma are not asso...
متن کاملDefining secondary progressive multiple sclerosis.
A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis,...
متن کاملModifying disability in progressive multiple sclerosis
www.thelancet.com Vol 383 June 28, 2014 2189 Multiple sclerosis is the most common cause of chronic neurological disability in young adults in developed countries and seems to be increasing in frequency. Disease presentation in 80–90% of patients follows an initial phase characterised by bouts of relapsingremitting neurological dysfunction. These relapses are thought to represent focal areas of...
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ژورنال
عنوان ژورنال: Multiple Sclerosis Journal
سال: 2019
ISSN: 1352-4585,1477-0970
DOI: 10.1177/1352458519848090